With a gap of five years, Darkness II is a sequel for the first part of the franchise following the story of James Estacado. After becoming the don of the Franchetti family, he still fights the fact that his girlfriend Jenny died in the first game and fighting against the Darkness itself. Things turn pretty bad when a group of attackers catch James and his men off guard in a restaurant. Being severely injured he still refuses this powers even if they save them. The attack doesn't end so fast, and after an explosion, James is left to bleed out and die. James gives up and embraces the Darkness fighting off his attackers and begins his fight with the Brotherhood and his own sanity.

The core feature of the game is to control the tendrils. Being Darknesses spawns, two tendrils will help the player to fight off his enemies. You can execute people, throw them around and throw things at them. Also, you can use it to merely attack or defend yourself in any fighting situation. In case you will want to do the campaign with your friends, the game gives you Vendetass. The plot of it follows four hitmen from Jackie's family to stop the mysterious Brotherhood.